Platform Background:
Nectid has developed a screening platform that utilizes known molecules to repurposing them novel indication. The initial goal is to conceptualize, design and synergistic platforms that improve the clinical profile of currently approved drugs by several orders of magnitude. The platform is disease specific, often mechanism specific, and uses thousands of training sets and corresponding biological responses and requires customization depending on the therapeutic area.

Nectid's proprietary software developed using disease specific biological responses of known bioactive and nutritional use compounds. The platform uses a sophisticated mathematical function to provide a screening tool to predict an active synergistic combination from hundreds of newly designed chemical entities. We are continuing to improve the platform by two approaches- 1) continual addition of training molecules and new biological responses relevant to that specific training molecule and 2) building a complementary molecular profile model.

For Example Nectidís FXR platform uses the ability of certain known compounds to cross mitochondrial barriers without the need for carrier enzymes and how it synergizes with peroxisomal lipid metabolism by a second known compound such a Docosahexaenoic acid \.

We discovered that there is a cross talk between peroxisome and mictochondria through signaling entity that is influenced by both molecules.

NFX-21:- NFX-21is a platform of Caprylic triglyceride, A known fatty acid that modulates beta oxidation in the mitochondria with Docosahexaenoic acid (DHA) which modulates peroxisomal oxidation of lipids. In healthy volunteer studies, the platform was found to improve whole cell energy homeostasis and lipid metabolism.

NFX:-22:- NFX-22 is a platform of Medium Chain Triglyceride (MCT) and Eicosapentaenoic Acid (EPA) or Docosahexaenoic acid (DHA) to generate enhanced ketone bodies in liver hepatocytes for use by brain retina and Muscles. The platform is unique because of its ability to increase ketone bodies concentration rapidly. The platform is useful in neurological disorders like epilepsy and it can be combined with another ingredient like caffeine, vitamin D etc.